Looking for:
- |
Windows 10 1703 download iso italy covid booster shots. CBPM promove II Fórum de Inovação e Sustentabilidade na Mineração na próxima quinta (9/6)
This update includes diagnostic improvements for determining the applicability как сообщается здесь updates in Windows 10 VersionVersionVersionand Version The files and resources in windows 10 1703 download iso italy covid booster shots update make sure that feature updates are installed seamlessly to improve the reliability and security of Windows Only certain builds of Windows 10 VersionVersionVersionand Version require this update. Devices that are running these builds automatically get the update downloaded and installed through Windows Update.
This update is also offered directly to Windows Update Client for some devices that have not installed the most recent updates. The English United States version of this software update installs files that have the attributes that are listed in the following tables. The dates and the times for these files on your local computer are displayed in your local time together with your current daylight saving time DST bias.
Additionally, the dates and the times may change when you perform certain operations on the files. Sign in with Microsoft. You're signed in. You have multiple accounts. Windows windows 10 1703 download iso italy covid booster shots More Need more help? Expand your skills. Get new features first. Was this information helpful? Yes No. Thank you! Any more feedback? The more you tell us the more we can help.
Can you help us improve? Resolved my issue. Clear instructions. Easy to follow. No jargon. Pictures helped. Didn't match my screen. Incorrect instructions. Too technical. Not enough information. Not enough pictures. Any additional feedback? Submit feedback. Thank you for your feedback!
File name. File version. File size.
Windows 10 1703 download iso italy covid booster shots. A MESSAGE FROM STEVEN WAGONER, VB CITY FC TEAM PRESIDENT
I was looking for this specific information for an amazingly yielded time-frame. Grateful to you and best of luck. My family proposed I could like this site. He was absolutely correct. This submit truly made me indescribably satisfied. Because studies show that a web lead like me will only hang out a few seconds — 7 out of 10 disappear almost instantly, Surf Surf Surf… then gone forever.
The new text messaging feature lets you follow up regularly with new offers, content links, even just follow up notes to build a relationship.
But all too often, they come up short when it comes to engaging and connecting with anyone who visits. Studies show 7 out of 10 people who land on a site, abandon it in moments without leaving even a trace. You got the eyeball, but nothing else. Plus, with text messaging you can follow up later with new offers, content links, even just follow up notes to keep the conversation going.
This is a great resource for everyone, and anyone may profit from using it. Search Search Close. Left Previous Next Right. Thank you, Steven A. Robertguals said: samsung galaxy s6 edge blue topazmorse code audio decoder macm audio revolution 7 1verizon galaxy note 4 lollipopyamaha tsr receiverevochron legacy free downloadmsi bm mortar driversacer veriton xg driversray games part 1asus x99 deluxe u3 1 asus rt n66w firmware atom text editor portable android 5. Robertguals said: dell wireless driver windows 10dawn of war 2 system requirementsgalaxy s5 lollipop t mobileamd radeon hd driverdell vostro s driversd link dfe txsamsung npp5c-a01ubhewlett packard flash driveslitchi tumblr photo downloaderdell inspiron pp41l drivers biostar agz bios update samsung galaxy s7 edge clone atom x5-z benchmark intel centrino wireless n epson gt driver galaxy grand prime 5.
Robertguals said: lenovo ideapad u driversdragon age morrigan hotm-audio lunarazer death adder driver downloaddream match tennis pro 2. Robertguals said: gigabyte gafxa-ud3 r5 rev. Robertguals said: marvel heroes promo codesrealtek rtlbs wireless lan Robertguals said: beyond the red linerampage v extreme bios updatega-f2a68hm-h manualdell t bios updatetoshiba bluetooth stack 9.
Robertguals said: avast endpoint protection pluscrusader diablo 3 voice actorgateway dxdr lunatic supreme with cheesemyth 2 soulblighter downloadintel hm87 chipset drivergoogle pixel xl vs lg g6epson gtge force gt mtotal war attila saxons lg flex 2 overheating beauty and the beast icon mionix naos software elitebook g2 drivers insert multiple pictures into word asus directcu ii drivers toshiba sleep and charge windows 10 microsoft bingo power ups wintv-pvr windows 10 windows home server toolkit halo back iphone 6 q7 android tv box firmware gigabyte g1.
Robertguals said: msi z gaming pro carbon driverssamsung dvd writer sh driver downloadsamsung bd p firmwarecorel painter reviewsteelseries siberia v3 prism driverssharp mx n driveruncharted 3 multiplayer mapsintel centrino ultimate-n agn driverdate almost anything endingssony handycam drivers for windows 7 asus m5a99fx pro r2. Robertguals said: farmville tropic escape boostsline 6 toneport ux1 driverfar cry 4 white tigercan i run deus ex mankind dividedm audio usb mic drivertoshiba satellite l drivers for windows 7 64 bit sony bravia kdlwbl-acoustics network managerreading blaster downloadstreet fighter 4 achievement flash player xbox lenovo power management driver windows 7 dell sd card driver windows 10 bravia kdlwb root lg gpad 8.
Robertguals said: attila total war pictsstreet fighter 4 achievementvital source converter pro serialhow to jailbreak ps3 4. Robertguals said: loren the amazon princess downloadms lifecam hd asus sabertooth fx gen3 r2.
Robertguals said: steelseries siberia v3 prism driverspioneer avic fbt updateamd radeon driver Just this alone could be a game changer to make your website even more effective.
Thanks and keep up the great work! Muhammad said: auto insurance companies car insurance quote best auto insurance get auto insurance online auto insurance price. Robertguals said: hp elitebook revolve driversubuntu touch nexus 10dota 2 6. Robertguals said: minecraft forum pocket editionlegend in fifa 15microsoft comfort keyboard driversskyrim lich king armorattila total war climate changegigabyte ga p35 ds3lati radeon hd driverschuwi hi8 android 5.
Robertguals said: asrock gm-gs3bigfoot lan driver windows 10tatsunoko vs capcom arcade stickqualcomm atheros arx driver windows 10rise of shadows bomb warriorevga geforce gtx fable 3 business partnersacer e driversdiner dash once upon a dinersteelseries apex gaming keyboard drivers ps3 jailbreak 4. Robertguals said: asrock — x masterquicktime for mac Robertguals said: rocketfish hd webcam driverricoh memory stick controllernetgear nighthawk r firmwarewhat is broadcom management programsricoh mp csr driverleague of legends extra bonus rpstandard vs alternative movement witcher 3sigmatel stac x ac97 audio driver windows 7diablo 3 identify itemsmp navigator ex 5.
Robertguals said: ga-z77m-d3h-mvplenovo tablet wont turn on or chargeps4 firmware 3. Robertguals said: broadcom 54g maxperformance Robertguals said: microsoft sculpt comfort bluetooth mouse driverdark dimensions shadow pirouettesunset overdrive voice castfootball manager transfer updatetoshiba satellite laptop bluetoothhp prodesk driversalcor micro usb card reader driver windows 7mad catz mmo teyoutube free downloader 4.
Robertguals said: nero 11 free downloadfallout 4 1. Robertguals said: sound blaster cinema 2 downloadadobe flash player Robertguals said: moldovencele sunt cele mai frumoasegta 5 ps3 dlc downloadbanner saga 2 against all oddsyoga 2 pro bios updatesurface network adapter driver gaming motherboard driversrealtek ae wireless lan You can fix this.
This could change everything for you and your business. Luigi C , Stefania DS. Nitrous oxide intoxication: systematic literature review and proposal of new diagnostic possibilities.
Egypt J Forensic Sci ; 12 Cancers ; 14 A scoping review of distributed cognition in acute care clinical decision-making. Diagnosis ; 0. Visual learning strategies for oral health promotion and treatment interventions in children and adolescents with hearing impairment — A systematic review. Special Care in Dentistry Association between polychlorinated biphenyl exposure and thyroid hormones: a systematic review and meta-analysis.
Risk factors of unilateral breast cancer-related lymphedema: an updated systematic review and meta-analysis of 84 cohort studies. Support Care Cancer ; 31 Int J Telerehab ; Univ Psychol ; 21 Laparoscopic vs.
Surg Endosc Aust Endodontic J Influence of smoking on the effectiveness of tooth whitening: a systematic review. Clin Oral Invest Watke M. The corrugator supercilii for craniofacial reconstruction: a systematic review.
Eur J Plast Surg Reprod Biol Endocrinol ; 20 J Neurol CNS Neurosci Ther A peek behind the curtain: An integrative review of sexual harassment of nursing students on clinical placement. Journal of Clinical Nursing Long-term survival in patients with node-positive breast cancer who undergo sentinel lymph node biopsy alone after neoadjuvant chemotherapy: meta-analysis.
British Journal of Surgery Animal movement ecology in India: insights from — and prospective for the future. PeerJ ; 10 :e Motor Control Physical activity promotion in chiropractic: a systematic review of clinician-based surveys.
Chiropr Man Therap ; 30 Dressing to prevent surgical site infection in adult patients with cancer: a systematic review with meta-analysis. The preferred technique for knee synovium biopsy and synovial fluid arthrocentesis. Rheumatol Int All-cause mortality after major gastrointestinal bleeding among patients receiving direct oral anticoagulants: a protocol for a systematic review and meta-analysis.
Syst Rev ; 11 Risk of non-hormonal cancer after bariatric surgery: meta-analysis of retrospective observational studies. Br J Surg znac J cachexia sarcopenia muscle Aggressive hydration for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis: trial sequential analysis. Sarcopenia as a risk factor of progression-free survival in patients with metastases: a systematic review and meta-analysis..
Socioeconomic position, built environment and physical activity among children and adolescents: a systematic review of mediating and moderating effects. Stains therapy and the risk of all bleeding and intracranial hemorrhage: A meta-analysis of randomized controlled studies. J Evid Based Med Global Spine J ; Healthcare ; 10 Long-term health outcomes of early menarche in women: an umbrella review.
QJM ; Multifamily interventions in the context of inherited genetic conditions: A scoping review. Journal of Family Therapy Neutrophil-lymphocyte ratio as a predictor of outcome following traumatic brain injury: Systematic review and meta-analysis.
JNRP ; 0 A Scoping Review. Neuropsychol Rev Comparison of rapid versus slow maxillary expansion on patient-reported outcome measures in growing patients: a systematic review and meta-analysis. Prog Orthod ; 23 JOIO Current Oncology ; 29 Therapeutic sensitivity to standard treatments in BRCA positive metastatic castration-resistant prostate cancer patients-a systematic review and meta-analysis.
Prostate Cancer Prostatic Dis Sports Med Open ; 8 Systematic review on post-stroke computerized cognitive training: Unveiling the impact of confounding factors. Front Psychol ; Transarterial chemoembolisation plus I seeds implantation for people with unresectable hepatocellular carcinoma. CD ] [ Reference Citation Analysis ]. Aeromedical retrieval services characteristics globally: a scoping review. Nutrients ; 14 Psychol Psychother Factors affecting ward nurses' basic life support experiences: An integrative literature review.
Int J of Nursing Practice Am J Health Promot Li L , Murakami S. Indian J Plast Surg Predicting neurological outcome in adult patients with cardiac arrest: systematic review and meta-analysis of prediction model performance.
Crit Care ; 26 The impact of botanical fermented foods on obesity, metabolic syndrome and type 2 diabetes: a systematic review of randomised controlled trials.. J of Clinical Hypertension Pharmacy ; 10 Journal of Voice Electrolyzed water for the microbiologic control in the pandemic dental setting: a systematic review.
BMC Oral Health ; 22 Are platelet concentrate scaffolds superior to traditional blood clot scaffolds in regeneration therapy of necrotic immature permanent teeth? A systematic review and meta-analysis. Are We Getting It Right?
Physical mobility determinants among older adults: a scoping review of self-reported and performance-based measures. European Journal of Physiotherapy Effect of the COVID pandemic on the proportion of physically active children and adults worldwide: A systematic review and meta-analysis.
Front Public Health ; Meaning in life, meaning-making and posttraumatic growth in cancer patients: Systematic review and meta-analysis. Asian J Androl Metabolites ; 12 Comparative efficacy of different acupuncture therapies on cancer-related insomnia: protocol for a systematic review and network meta-analysis. BMJ Open ; 12 :e Emerging technologies in facility management in Brazil. JFM How efficacious are traditional Chinese medicine injections in treating angina pectoris?
A network meta-analysis of randomized controlled trials. J Ethnopharmacol ; Quality of life of patients and caregivers affected by bronchopulmonary dysplasia: a systematic review. Qual Life Res Investigating the impact of pre-slaughter management factors on meat quality outcomes in cattle raised for beef: A scoping review. Front Anim Sci ; 3. Characteristics, methodological, and reporting quality of scoping reviews published in nursing journals: A systematic review.
J of Nursing Scholarship Systematic and evaluative review of school climate instruments for students, teachers, and parents. Psychology in the Schools Impact of physical exercise programs in breast cancer survivors on health-related quality of life, physical fitness, and body composition: Evidence from systematic reviews and meta-analyses.
Front Oncol ; Malnutrition among the aged population in Africa: A systematic review, meta-analysis, and meta-regression of studies over the past 20 years. PLoS One ; 17 :e Han A , Kim TH. J Med Internet Res ; 24 :e CBT treatment delivery formats for panic disorder: a systematic review and network meta-analysis of randomised controlled trials. Psychol Med Nursing Open Associations between diabetic retinopathy, mortality, disease, and mental health: an umbrella review of observational meta-analyses.
BMC Endocr Disord ; 22 Falah Jamal Dakka. Oncol Ther Utilisation, effectiveness, and safety of immediate postpartum intrauterine device insertion: a systematic literature review. Acceptability and feasibility of continuous glucose monitoring in people with diabetes: protocol for a mixed-methods systematic review of quantitative and qualitative evidence.
Global Health ; Front Aging Neurosci ; Daytime napping and coronary heart disease risk in adults: a systematic review and dose—response meta-analysis. Sleep Breath Diagnostics ; 12 Does surgically assisted maxillary expansion improve obstructive sleep apnoea in adults?
Evid Based Dent IJMS ; 23 Int J Artif Intell Educ Eur J Pediatr The British Journal of Social Work Advanced practice nurse capabilities: A mixed methods systematic review. Scandinavian Caring Sciences Effects of psychological treatments on functioning in people with Schizophrenia: a systematic review and meta-analysis of randomized controlled trials.
Eur Arch Psychiatry Clin Neurosci An overview of systematic reviews on endotoxins in endodontic infections and the effectiveness of root canal therapy in its removal.
VOR gain of lateral semicircular canal using video head impulse test in acute unilateral vestibular hypofunction: A systematic review. Front Neurol ; Burn E , Waring J. The evaluation of health care leadership development programmes: a scoping review of reviews. LHS Does self-sampling for human papilloma virus testing have the potential to increase cervical cancer screening?
An updated meta-analysis of observational studies and randomized clinical trials. Fundoplication in laparoscopic Heller's cardiomyotomy for achalasia. Toward revising dietary zinc recommendations for children aged 0 to 3 years: a systematic review and meta-analysis of zinc absorption, excretion, and requirements for growth.
Nutrition Reviews Treatment and outcomes of peritonitis due to Rothia species in patients on peritoneal dialysis: A systematic review and multicentre registry analysis. Perit Dial Int Caffeine and cerebral palsy: A systematic review of randomized controlled trials and cohort studies.
Complement Ther Med ; 72 Outcomes of graciloplasty in the treatment of fecal incontinence: a systematic review and meta-analysis of the literature. Tech Coloproctol The impact of sugar-sweetened beverages tax on oral health-related outcomes: a systematic review of the current evidence. Impact of peritoneal dialysis modality on patient and PD survival: A systematic review.
Panax notoginseng preparation plus aspirin versus aspirin alone on platelet aggregation and coagulation in patients with coronary heart disease or ischemic stroke: A meta-analysis of randomized controlled trials.
Front Pharmacol ; Henrotin JB , Gulisano F. Sick leave during pregnancy and occupational factors: a systematic review. Occup Med Lond ; 72 Understanding the risk of developing weight-related complications associated with different body mass index categories: a systematic review.
Diabetol Metab Syndr ; 14 The development of the concept of return-on-investment from large-scale quality improvement programmes in healthcare: an integrative systematic literature review. Brain Sciences ; 12 Med Sci Educ A comprehensive systematic review of colorectal cancer screening clinical practices guidelines and consensus statements. Br J Cancer ; Lipids Health Dis ; 21 Motor cortical inhibitory deficits in patients with obsessive-compulsive disorder—A systematic review and meta-analysis of transcranial magnetic stimulation literature.
Front Psychiatry ; Pharmaceutics ; 14 JCO Oncology Practice Efficacy and safety of total glucosides of paeony in the treatment of systemic lupus erythematosus: A systematic review and meta-analysis.
Simplified stroke imaging selection modality for endovascular thrombectomy in the extended time window: systematic review and meta-analysis. J NeuroIntervent Surg Vaccines ; 10 Behavioral Sleep Medicine Interventions simultaneously promoting social participation and physical activity in community living older adults: A systematic review.
Int J Nephrol Renovasc Dis ; 15 S ] [ Reference Citation Analysis ]. The clinical effect of radiotherapy on pulpal microvasculature: a systematic review. Br Dent J Social prescribing of nature therapy for adults with mental illness living in the community: A scoping review of peer-reviewed international evidence. Leadership and well-being of employees in the Nordic countries: A literature review.
WOR The sphenoidal emissary foramina prevalence: a meta-analysis of 6, subjects. Surg Radiol Anat J Alzheimers Dis ; 90 The association between testosterone and depression in postmenopausal women: A systematic review of observational studies.
Maturitas ; Nutrients ; Rheumatol Ther What are the nursing competencies related to antimicrobial stewardship and how they have been assessed? Results from an integrative rapid review. Antimicrob Resist Infect Control ; 11 Sustainability ; 14 A systematic review on methods for developing and validating deprescribing tools for older adults with limited life expectancy.
International Journal of Pharmacy Practice Life ; 12 Motor competence interventions in children and adolescents — theoretical and atheoretical approaches: A systematic review. Journal of Sports Sciences Martinou E , Angelidi A. The role of open research in improving the standards of evidence synthesis: current challenges and potential solutions in systematic reviews. FRes ; 11 Zhen LS , Hashim H. Neuromodulatory effects of transcranial magnetic stimulation on language performance in healthy participants: Systematic review and meta-analysis.
Front Hum Neurosci ; Experiences of patients and their family members with metachromatic leukodystrophy, adrenoleukodystrophy, and Krabbe disease: a qualitative systematic review protocol. A hostile context, very limited intervention theory and almost no change in outcomes: findings from a systematic realist review of health passports for Autistic adults.. Sarah Filiatreault , Jeremy M.
Grimshaw , Sara A. A critical appraisal of delirium clinical practice guidelines relevant to the care of older adults in the emergency department with a synthesis of recommendations: an umbrella review protocol. Vascular dysfunction in juvenile idiopathic arthritis: a systematic review and meta-analysis.
Effect of a gluten-free diet on bone mineral density in children and adolescents with celiac disease: Systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition BioMed Research International ; Probiotics for preventing or treating COVID; a systematic review of research evidence and meta-analyses of efficacy for preventing death, severe disease, or disease progression.
Wellcome Open Res ; 7 Int J Mol Sci ; Cancer Epidemiol Biomarkers Prev ; 31 Surgical strategies for chondral defects of the patellofemoral joint: a systematic review.
J Orthop Surg Res ; 17 Early Child Development and Care Vagus nerve stimulation paired with rehabilitation for motor function, mental health and activities of daily living after stroke: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry The family side of work-family conflict: A literature review of antecedents and consequences.
JFamRes ; 34 Meta-analytic study on substance intake and work-related accidents calls for attention to bio-psycho-social factors. Neurosci Biobehav Rev ; Influence of cohousing communities on social determinants of health in later life: a scoping review protocol. Therapeutic Hypothermia and Temperature Management Parameters associated with successful weaning of veno-arterial extracorporeal membrane oxygenation: a systematic review.
Reprod Sci Examining the existing knowledge base for enablers of family recovery in mental health: a protocol for a scoping review of national and international literature. Dentistry Journal ; 10 J Hosp Infect S 22 Perioperative and oncologic outcomes of single-port versus conventional robotic-assisted partial nephrectomy: an evidence-based analysis of comparative outcomes. J Robotic Surg Viruses ; 14 Sports ; 10 JAMA Neurol JAMA Pediatr The prevalence of hypertension in paediatric Turner syndrome: a systematic review and meta-analysis.
J Hum Hypertens Effects of evidence-based clinical practice guidelines for breast cancer in health care quality improvements. A second systematic review. Psychosocial attributes of housing and their relationship with health among refugee and asylum-seeking populations in high-income countries: systematic review..
Comparative analysis between radioactive seed localization and wire-guided for non-palpable breast cancer surgery. Braz J Rad Sci ; J Clin Med ; Clin Drug Investig Effects of biologic and target synthetic disease-modifying anti-rheumatic drugs on sarcopenia in spondyloarthritis and rheumatoid arthritis: a systematic review and meta-analysis. Clin Rheumatol Extracorporeal shockwave therapy compared with standard care for diabetic foot ulcer healing: An updated systematic review. International Wound Journal Effects of vaccine registration on disease prophylaxis: a systematic review.
Biomed Eng Online ; 21 Applied Sciences ; 12 Transvaginal ultrasound versus magnetic resonance imaging for diagnosing adenomyosis: A systematic review and head-to-head meta-analysis. Int J Gynaecol Obstet The association between albumin levels and survival in patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis.
Front Mol Biosci ; 9. Journal of Positive Behavior Interventions Investigating the impact of pre-slaughter management factors on indicators of fed beef cattle welfare — a scoping review. Quality improvement interventions to prevent unplanned extubations in pediatric critical care: a systematic review.
Animals Basel ; Antifibrinolytics use during surgery for oncological spine diseases: A systematic review. Surgical Neurology International ; 13 Impact of energy density on energy intake in children and adults: a systematic review and meta-analysis of randomized controlled trials.
Eur J Nutr Investg Enferm Imagen Desarollo Association between asthma and oral conditions in children and adolescents: a systematic review with meta-analysis. Effect of vitamin K on wound healing: A systematic review and meta-analysis based on preclinical studies. Do task and item difficulty affect overestimation of one's hand hygiene compliance? A cross-sectional survey of physicians and nurses in surgical clinics of six hospitals in Germany. Statin intolerance management: a systematic review.
Endocrine Effect of alirocumab and evolocumab on all-cause mortality and major cardiovascular events: A meta-analysis focusing on the number needed to treat. Front Cardiovasc Med ; 9.
Contact Dermatitis Children ; 9 A systematic review of learning path recommender systems. Educ Inf Technol The use of Virtual Reality in pain management during the burn wound dressing change in children: systematic review and meta-analysis.. An investigation of Reablement or restorative homecare interventions and outcome effects: A systematic review of randomised control trials. Health Social Care Comm Sodium fluorescein in pediatric neurosurgery: a systematic review with technical considerations and future perspectives.
Systematic review to identify proxy measures to assess post-stroke functional outcomes. Health Sciences Review ; 5 Pharmacologic therapies of pain in patients with spinal cord injury: a systematic review. Spinal Cord Ser Cases ; 8 The role of serum-free light chain ratios in the prediction of poor prognosis in multiple myeloma patients: a systematic review and meta-analysis.
Hematology ; 27 Second primary malignancies in patients with haematological cancers treated with lenalidomide: a systematic review and meta-analysis. The Lancet Haematology ; 9 :ee LSE ; Methamphetamine-associated heart failure: a systematic review of observational studies. Heart An evaluation of global Chikungunya clinical management guidelines: A systematic review.
Determining the safety and effectiveness of percutaneous nephrolithotomy and retrograde intrarenal surgery in treating nephrolithiasis in patients with solitary kidneys. Urolithiasis ; 51 The adverse effects of long-term exposure to antipsychotics among older people with intellectual disabilities: a scoping review. HRB Open Res ; 5 Neurorehabil Neural Repair ; 36 Machine learning methods for the study of cybersickness: a systematic review. Brain Inf ; 9. Spitschan M. Reproducibility in sleep and circadian science systematic reviews and meta-analyses.
Sleep Med Rev ; 66 Arch Phys Med Rehabil ; J Dent ; Effects of a single exercise session on pain intensity in adults with chronic pain: a systematic review and meta-analysis. Musculoskelet Sci Pract ; 62 Martin JE , Tyndall D. J Nurs Educ ; 61 Eur Urol Oncol ; 5 Efficacy and safety of leflunomide combined with corticosteroids for the treatment of IgA nephropathy: a Meta-analysis of randomized controlled trials.
Ren Fail ; 44 Weining C. Listening Modes in Concerts. Music Perception ; 40 Effects of physical exercise in people with epilepsy: A systematic review and meta-analysis. Clinics and Research in Hepatology and Gastroenterology ; 46 Barriers and enablers to implementing and using clinical decision support systems for chronic diseases: a qualitative systematic review and meta-aggregation.
Implement Sci Commun ; 3 The American Journal of Dermatopathology ; 44 A Systematic Review with Meta-analysis.
Sports Med - Open ; 8 Risk of dry eye in headache patients: a systematic review and meta-analysis. Ann Med ; 54 A mixed-method cluster analysis of physical computing and robotics integration in middle-grade math lesson plans. A meta-analysis of observational studies that includes , individuals reported 13, events of blood pressure abnormal or increased 2. These events have been often described as short periods of hypertensive response and often observed in patients with risk factors.
Conclusion: Our results confirmed a signal of risk of events of elevated blood pressure following immunization with COVID vaccines.
However, there is no evidence that these episodes could result in serious complication typically associated with hypertension, such as stroke, aneurysms, heart failure, myocardial infarction and chronic kidney disease. Introduction: Intravitreal drugs such as bevacizumab, ranibizumab, and aflibercept are widely used to treat a wide range of retinal diseases.
Several studies suggest that repeated injections of these drugs may lead to a sustained rising of intraocular pressure increasing risk for glaucoma. To date, a comparative safety study of these three drugs with respect to the incidence of glaucoma diagnosis has not been done. Objective: The objective of this study was to evaluate the risk of glaucoma diagnosis compared among new users of bevacizumab, ranibizumab, and aflibercept in Tuscany.
Methods: A retrospective cohort study using the Tuscan regional administrative database was conducted. Subjects with a first intravitreal injection index date between January —June were identified and followed to the first occurrence of glaucoma diagnosis. Patients with less than a five-year look-back period, those with less than one year of follow-up, and those with previous use of intravitreal dexamethasone, diagnosis of diabetes or glaucoma were excluded.
We also excluded patients for whom we could not track the first injection to bevacizumab, ranibizumab or aflibercept. Glaucoma diagnosis was identified from exemptions, diagnosis in hospital discharge records or drug dispensations.
An intention-to-treat analysis was conducted to analyze risk of glaucoma diagnosis between the three drugs. A Cox model was constructed to compute hazard ratios adjusting for age, sex comorbidities, corticosteroid use and binocularity. The risk of incident glaucoma diagnosis compared to aflibercept was significantly higher among non-anticoagulant users who had received ranibizumab HR 2.
Among anticoagulant users no statistically significant difference was observed. Moreover, we found an increase in the risk of glaucoma with ranibizumab and bevacizumab compared to aflibercept among non-anticoagulant users.
A time dependent exposure analysis is ongoing to confirm these results. Introduction: A method of time-to-onset TTO signal detection for screening unexpected temporal patterns from vaccine spontaneous report data has been published in [1]. Due to the large number of spontaneous reports associated to covid vaccines, highly significant TTO signals could be detected whereas there are no clinically relevant unexpected temporal patterns.
Methods: The revised method used only the most predictive measure [3] of the two Kolmogorov-Smirnov KS tests originally designed: the p-value of the KS test of the TTO distribution of a given event post a given vaccine against the TTO distribution of the same event post other vaccines.
A threshold on the Kolmogorov-Smirnov distance, that can have values between 0 and for no difference between time-to-onset distributions and 1 for extreme differences—was set at 0.
A threshold on the p-value of the KS test was set at 0. The Vaccine Adverse Event Reporting System was prospectively frozen every week of the first quarter and the revised TTO signal detection method was prospectively applied on the two covid vaccines. The performance in detecting events that were posteriori determined as causally related to the exposure of the covid vaccines, namely Pericarditis and Myocarditis, was retrospectively assessed.
Conclusion: The revised TTO method allowed early detection of unexpected TTO patterns post exposure to covid vaccines by controlling both the level of significance and the magnitude of difference between the TTO distributions in a context of mass vaccination where individual case review is challenging.
Van Holle L et al. Using time-to-onset for detecting safety signals in spontaneous reports of adverse events following immunization: a proof-of-concept study, PDS 21 6 , — Use of logistic regression to combine two causality criteria for signal detection in vaccine spontaneous report data, Drug Safety 37 12 , — With the fast-tracked development and concurrent introduction of vaccines in all countries, there is a need for equitable safety surveillance to monitor adverse events following immunization AEFIs in high-income and low- and middle-income countries LMICs.
Reports from females made up The highest number of reports came from persons 18—44 years. Sputnik V contributed the highest percentage of AEs per vaccine for Africa. Headache, pyrexia, injection site pain, dizziness, and chills were the top 5 reported AEs for Africa and RoW.
Qualitative findings revealed decisions of many funding organizations to fund safety surveillance in LMICs were influenced by considerations about country priorities, the perceived utility of the evidence generated for local decision making, and the contributions to global health by safety surveillance systems. Funding decisions by donor organizations were influenced by country priorities and the perceived value added by data generated from safety surveillance systems in LMICs to local and global decision making.
Coronavirus Vaccine Tracker. The New York Times [Internet]. Introduction: Therapeutic advances have reduced morbidity and mortality, but have led to an increase in adverse drug events ADE. This is a case-control type study, with the original information from the administrative data from the hospital information system of the public health system in Brazil-SIH-SUS, in the period from to After applying the exclusion criteria, , hospital admissions associated with at least one ADE were included in the study.
The proportion of patients with ADE in hospitalizations was 0. Drug poisoning and drug abuse are the adverse event classes most associated with increased risk of death.
This study, confirm that the SIH-SUS is a robust source of data for the field of pharmacovigilance, enabling the identification of risk factors for death and facilitating the monitoring of ADEs in the hospital environment. Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis.
Prospective identification versus administrative coding of adverse drug reaction-related hospitalizations in the elderly: A comparative analysis. Pharmacoepidemiol Drug Saf. Evaluating adverse drug event reporting in administrative data from emergency departments: a validation study. Stausberg J, Hasford J. Drug-related admissions and hospital-acquired adverse drug events in Germany: a longitudinal analysis from to of ICDcoded routine data.
Introduction: Transplant recipients are chronically ill patients, who require lifelong drug therapies to prevent reject and graft loss. To date, there is no consensus on the optimal immunosuppressive strategy []. Objective: The aim of the study was to assess the effectiveness and safety of maintenance immunosuppressive drug therapies in kidney transplant. Methods: A retrospective multicentre observational study, involving 4 Italian regions, was conducted based on the national transplant Information system and regional healthcare claims data.
Specifically, the regional analytical datasets regarding incident patients underwent to kidney transplant in the years —19 were created using an open-source tool for distributed analysis. Results: Overall, 3, kidney recipients were considered, of which During a median follow-up period of 4. Among safety outcomes, serious infections had the highest incidence 9.
Conclusion: In clinical practice, a significantly better benefit profile has been demonstrated for kidney recipients treated with TAC compared to CsA. In particular, the combination of TAC and mTOR appears to be the optimal strategy reducing the incidence of severe infections. Our findings on long term risk-benefit profile of immunosuppressive therapy may be helpful to define the optimal drug therapy in kidney recipients. Comparison of tacrolimus and cyclosporine for immunosuppression after renal transplantation: An updated systematic review and meta-analysis.
Saudi J Kidney Dis Transpl. Target of rapamycin inhibitors TOR-I; sirolimus and everolimus for primary immunosuppression in kidney transplant recipients.
Cochrane Database Syst Rev. Timing of mTORI usage and outcomes in kidney transplant recipients. Int J Med Sci. Published Jan 9. Due to the small sample size of pivotal trials in pediatrics, real-world evidence on the safety of those vaccines in the pediatric population is urgently required.
Objective: i To investigate the safety of COVID vaccines by measuring frequencies of solicited and serious adverse events following immunization AEFIs with the first and the second doses of vaccines through active surveillance and, ii to compare the results with the published clinicaltrials in children and adolescents.
Of them, only Overall, Conclusion: This study confirmed safety profile of COVID vaccines in the pediatric population as already documented in the pivotal trials, with a high frequency of local solicited adverse events and an extremely low rate of serious adverse events.
Introduction: Advances in the treatment of cancer in young patients have led to great improvements in life expectancy. However, treatment with chemo or radiotherapy causes reduction of sperm counts often to azoospermic levels that may persist for several years or be permanent. Oligospermia or azoospermia and long-lasting testicular atrophy are common adverse consequences of cancer treatment 1. Cases of oligospermia and azoospermia were identified using MedDRA v No Dis-Rep was found for any of the 14 AA TKIs: acalabrutinib, axitinib, cabozantinib, dacomitinib, lenvatinib, neratinib, nintedanib, pazopanib, ponatinib, regorafenib, sorafenib, sunitinib, tivozanib and vandetanib.
The analysis in VigiBase database yielded similar results. Our results however, should be interpreted with caution as disproportionality analyses are hypothesis generating rather than hypothesis testing. Meistrich, M. Clinical drug investigation. Bate A, Evans S. Quantitative signal detection using spontaneous ADR reporting.
A comparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions. Skin lightening products contain high concentrations of harmful ingredients such as hydroquinone, mercurials, and corticosteroids, and are reported to cause serious complications such as hyperpigmentation, exogenous ochronosis, wound dehiscence, nephropathy, steroid addiction syndrome, predisposition to infections, and other endocrinologic complications.
Despite all these public health risks, they have been used in many countries without regulation and consultation of healthcare professionals 3. Similarly, in Eritrea, there is uncontrolled marketing and use of SLAs even those with banned harmful ingredients. Objective: This study was conducted to assess the perception and utilization of SLAs among females of Asmara, the capital city of Eritrea. Methods: A cross-sectional descriptive study was conducted in representative samples of all beauty salons available in Asmara between May and July The study participants were selected using two-stage stratified cluster sampling technique.
The data collected through face-to-face interview was entered and analyzed using CSPro 7. Results: The study enrolled females. The majority of the respondents agreed that SLAs can make someone white About two-third Of those who ever used SLAs, About half of the respondents With the use of SLAs, Employed females AOR: 1.
Conclusion: Utilization of SLAs among females was prevalent. They were satisfied with its use despite experiencing adverse effects which urges coordinated efforts in tightening the regulation of cosmetics in general and establishment of cosmetovigilance systems in particular.
Widespread use of toxic skin lightening compounds: medical and psychosocial aspects. Dermatologic Clinics, Afr Health Sci. The global prevalence and correlates of skin bleaching: a meta-analysis and meta-regression analysis. Int J Dermatol. Introduction: Drug therapy in paediatrics is often associated with uncertainties due to lack of data from clinical trials. Due to this off-label use, missing paediatric dosage forms and complex dose calculations, medication errors ME occur up to three times more frequently compared to adults [3].
Objective: The aim of the study was to investigate the nature, characteristics and preventability of drug-related hospital admissions in paediatrics.
If parents had given consent for data transfer and further analysis, the suspected ADRs resp. MEs were subsequently validated by a blinded, independent expert team [6]. All ADRs and MEs were assessed with regard to their nature, preventability, severity and drug association.
Results: Of Consent for further analysis was obtained for 9. Allergic conditions, seizures incl. Treatment noncompliance, accidental exposure to product and dosing problems mainly underdosing were primarily identified as MEs in connection with the use of antiepileptic drugs, insulins and analogues and other beta-lactam-antibacterials. Conclusion: Drug-related hospital admissions play a significant role in paediatrics. Moreover, almost half of them are considered preventable and therefore result in unnecessary harm and treatment costs.
Dosing databases, training, and systematic screening for ADRs and MEs have great potential to increase the safety of drug therapy in children. Kimland, E. Odlind, Off-label drug use in pediatric patients.
Clin Pharmacol Ther, Magalhaes, J. Eur J Clin Pharmacol, Kaushal, R. JAMA, Smyth, R. PLoS One, Gallagher, R. Schulze, C. J Patient Saf, The lack of staff trained in PV is one of the most serious limiting factors affecting the development of PV in resource-constrained settings. Previous experiences suggest that blending learning programmes can be implemented in resource-limited countries to train health care professionals HCP with remarkable gains in terms of knowledge acquisition.
Methods: We developed the blended-courses integrated with a Train of Trainers scheme [1]. Two e-learning courses were made available on a web-based application, together with a manual on how to combine the e-learning courses together with face-to-face interactions. The blended course were given in Tanzania, Eswatini and Nigeria.
Results: In the three countries 95 participants were trained Table 1. All participants completed the two courses and the mean score of the post-test was significantly greater than on the pre-test Table 1.
In the second level, the participants from the first training were training others. The majority of respondents to questionnaires have been satisfied, declared they felt more involved in PV and reported at least an ADR after the training both in the first and second level.
The trends of reporting increased in the twelve months after the training if compared to the previous twelve months: vs and vs ICSRs were reported to Vigibase for Tanzania and Eswatini National Agency respectively. Conclusion: Our results demonstrated that a blended course can reach an important number of participants and improve their knowledge.
It is difficult to establish how much of the increase of reports was attributed to the blended learning training.
Alammary A. Blended learning models for introductory programming courses: a systematic review. Plos one. The views and opinions of authors expressed herein do not necessarily state or reflect those of EDCTP. Introduction: Considering data from the literature in favor of active educational intervention to teach pharmacovigilance, we describe an innovative model of distance learning clinical reasoning sessions CRS of pharmacovigilance with 3rd year medical French students.
Objective: The three main objectives were to identify the elements necessary for the diagnosis of an adverse drug reaction, report an adverse drug reaction and perform drug causality assessment. Methods: The training was organized in 3 stages. First, students practiced clinical reasoning CRS by conducting fictive pharmacovigilance telehealth consultations.
Second, students wrote a medical letter summarizing the telehealth consultation and analyzing the drug causality assessment. This letter was sent to the teacher for a graded evaluation. In the third stage was a debriefing course with all the students. Results: Of the third-year medical students enrolled in this course, participated in the distance learning CRS.
The evaluation received feedback from students, with an average score of 8. The qualitative evaluation had only positive feedback. The students appreciated the different format of the teaching, with the possibility to be active. Conclusion: Through distance CRS of pharmacovigilance, medical students' competences to identify and report adverse drug reactions were tested. The students experienced the pharmacovigilance skills necessary to detect adverse drug reactions in a manner directly relevant to patient care.
The overall evaluation of the students is in favor of this type of method. Methods: This research used a qualitative inductive methodology through thematic analysis. The first step was to identify, through a literature review, current practices for herbal pharmacovigilance. Based on the findings a semi-structured interview guide was designed, and purposive sampling was used to recruit the interview participants.
By using a snowballing technique more potential participants were reached. Most of these recommendations are applicable worldwide, while some are limited to certain regions. Tong, A. Consolidated criteria for reporting qualitative research COREQ : a item checklist for interviews and focus groups. International Journal for Quality in Health Care, 19 6 , — Introduction: Although medical cannabis MC has been available in Canada since , lack of recognition of MC as a drug has restricted patient access.
The Quebec College of Physicians, between and , authorized MC use only within a research framework. Follow-up ended due to either MC discontinuation, loss to follow-up, 3 years follow-up, or end of data collection May , 6 months after the last patient in. Data were collected at inclusion and at follow-up visits every 3 months for the first 2 years, then at least once per year in the third year.
MC mode of administration ingestion, inhalation, other , and cannabinoid content ratio tetrahydrocannabinol THC -dominant, cannabidiol CBD -dominant, or balanced were documented. Results: 2, patients were enrolled in the registry mean age Over follow-up, 3. Reports included a total of AEs average 1. The most common PTs were dizziness Conclusion: There were no new safety concerns identified in the Registry, although notable differences in AE profile between modes of administration and cannabinoid content ratios should be considered by health professionals.
Further work identifying and managing risk factors for AEs is warranted to maintain a favorable risk-benefit ratio for MC. Introduction: Dengue is one of top ten global health threats and is a serious burden in the Philippines.
Dengvaxia immunization program was launched on April for children 9—year-olds in three regions with high statistics of dengue, hospitalization, and deaths. This was coincidentally the campaign period for national elections. Use of vaccine, once available, was part of a strategy to control epidemic. Current measures were inadequate. What started as vaccine-vigilance information sparked a public outcry. This led to a series of parliamentary investigations, traditional and social media misinformation and disinformation vilifying the health decision makers and the company, and criminal charges filed against over 20 individuals by the state over alleged unproven vaccine caused deaths.
Despite attempts to correct these narratives by a few health professionals, the damage to institution, the program, the product, and individuals have been done. The consequences of such actions of emotional approach without understanding the science have resulted in creating general vaccine rejection, hesitancy, other outbreaks such as measles, lowered confidence even with recent COVID vaccines.
Objective: This abstract aim to describe the situation at that time in the Philippines and extract lessons that will inform better risk communications during crisis.
Results: Some of the important lessons learned are in risk management and communications. Adverse health product information should be announced with circumspect considering the level of health literacy and risk appreciation in a country.
Partisan politics interfered with poorly understood science, fueled by imprudent comments by officials and health professionals who spoke out of turn, amplified by the media and created chaos. The fear was so palpable that enlightened health professionals refused to provide countervailing facts. Reinstating the vaccine would be perceived as the government had back-pedaled on a mistake.
In the meantime, the drama contributed to vaccination hesitancy and outbreaks. Conclusion: Public health decisions are policy and regulatory decisions anchored in ethical and utilitarian principles. Edillo et al. Economic Cost and Burden of Dengue in the Philippines. Vannice, et al Mendoza, Dayrit, Valenzuela. Dengue researcher faces charges in vaccine fiasco.
Lasco et. Medical populism and immunisation programmes: Illustrative examples and consequences for public health. Trolleyology and the Dengue Vaccine Dilemma. Dayrit, Mendoza, Valenzuela The importance of effective risk communication and transparency: lessons from the dengue vaccine controversy in the Philippines.
Dengue vaccination: a more balanced approach is needed. Introduction: Vaccines are vital tools to control epidemic and pandemic diseases, such as COVID, demonstrating safety and effectiveness. However, rare adverse events of special interest AESIs following vaccination arise with every new emerging pathogen vaccine program. Adversomics, a set of technologies that measure the inventory of molecules e. The International Network of Special Immunization Services INSIS brings together vaccine safety, public health, and systems biology experts in middle- and high-income countries to investigate the causes of, and identify strategies to mitigate AESIs following vaccination insisvaccine.
Brighton Collaboration case definitions and harmonized protocols will be employed to collect detailed clinical data and serial blood samples suitable for adversomics e. Integration of clinical and biological data will enable comparisons of analyte levels and immune responses within groups over time and between cases and controls. Global collaboration across five continents will ensure adequate sample size. Conclusion: INSIS-led studies will provide insight into pathways triggered in these AESIs and susceptible populations to inform vaccine development strategies to reduce the potential to trigger pathways involved in AESIs, risk-benefit assessment, and personalized vaccination strategies.
Introduction: During the covid 19 period, several countries needed to set up or develop their pharmacovigilance systems, unfortunately containment and the closure of borders prevented the organisation of classic training sessions. Objective: The objective of this work is to present the pharmacovigilance simulation game developed by CAPM, RCC and the results of its pilot use with pharmacovigilants from 10 French-speaking African countries.
The game is based on good practices in Pharmacovigilance PV , and inspired by the different WHO guidelines, the experience of the Moroccan PV center, and behaviors consensually considered as the norm in PV. In fact, they are put in a real-life situation to choose actions and strategies for the development of a PV center and must be able to optimize the human and material resources at their disposal to make their center shine within their national health system but also at the level of the international PV network.
Better understand the challenges and outlooks linked to the creation and management of a PV center. Put into practice the theoretical concepts in causality assessment, signal detection and risk minimization actions. During the game, within 10 levels, participants have to set up a PV center following WHO pharmacovigilance indicators: a practical manual for the assessment of pharmacovigilance systems as structural indicators, process indicators and outcome indicators, and following the pharmacovigilance process from collecting data, analyzing them, detecting signals, and setting up national technical pharmacovigilance committee to discuss about safety signals and risk minimization actions to put in place.
Conclusion: The use of the game by the pharmacovigilantes during the pilot phase gave good feedback on the ease of use and the effectiveness of the game in capacity building in pharmacovigilance. University of Huddersfield, Huddersfield, pp. Introduction: Pharmacovigilance has traditionally been a reactive science with a significant dependence on spontaneous adverse event reporting.
The pandemic on the other hand has accelerated application of novel technologies and approaches to engaging with the patient, remote connected care at their home and dependence on technologies to supplement regular communication channels. Telemedicine is evolving rapidly and playing a key role in clinical interventions. Objective: Digital Health and novel technologies offer a significant opportunity to enhance pharmacovigilance thru proactive patient monitoring, risk communication, personalized care plans and access to real world data.
Leveraging such approaches will not only lead to early detection of risks but also to personalized interventions and improved patient outcomes. Educational material which is more interactive, visual and multi-dimensional can replace paper or text based risk communication material. This could provide early signal detection in individual patients and enable proactive patient level pharmacovigilance.
Educational and risk related material can be dynamically updated based on patient preferences, interactions and profiles. Machine learning approaches which link material with outcome can enhance impact of pharmacovigilance methods and tools.
In order to utilize the full potential of such options it is critical that the regulatory framework is updated to enable such approaches which complement traditional PV and can drive efficiencies and higher effectiveness in the risk communication process. Collaboration within the network of industry and regulators is essential to further such research and maximize the impact on value for patients, HCPs and sponsors. Introduction: Large amounts of data associated with safety issues are generated along the entire lifetime of drugs, from its infancy as preclinical leads, through its adolescence as clinical candidates, all the way up to its adulthood as marketed drugs exposed to the human population.
Across the different stages in the life of a drug, some of the data collected initially may be confirmed and consolidated with data at an advanced stage, whereas other data may not be translated, and in some cases may even contradict, those safety signals that are ultimately observed in the human population. Collecting and properly integrating such an heterogenous pool of data is a complex and tedious task. But even if one manages to put all data together, the construction of useful models to anticipate and detect drug safety signals remains a challenge.
Objective: The presentation will cover our efforts to connect data from in vitro safety pharmacology, preclinical toxicology, clinical safety and post-marketing spontaneous reports for over 9, small molecule drugs, combination drugs, and biologics. A novel consensus approach using various statistical and machine learning methods to anticipate side effects of potential safety concern, detect adverse drug reaction signals and perform pharmacovigilance analyses will be introduced.
Use case application examples to individual drugs and drug classes will be discussed. Methods: Our consensus approach to post-marketing surveillance integrates four different methodologies based on detection of prior safety markers, identification of class reactions, statistical projection of disproportionalities based on reporting frequencies and velocities, and machine learning models of translational safety data.
Results: Results on the validation of our approach to anticipating adverse drug reactions of safety concern to the population at the postmarketing stage based on i in vitro safety pharmacology data, ii preclinical toxicology data, iii clinical safety data and iv the first sample of 25 postmarketing spontaneous reports will be presented.
Based on data available in each case, the performance of the different methods varies for different drugs, drug classes, and side effects. A discussion on performances in selected use cases will be included. As an example, the analysis of long-term PARP inhibition on circadian patterns and its dependence on the reporting bias by consumers will be discussed.
Conclusion: Integration and modelling of the large amount of translational safety data currently available from all phases of drug discovery, development and post-marketing to anticipate and follow adverse drug reactions opens an avenue to a whole new perspective in pharmacovigilance. Introduction: Psychedelics are unique psychoactive chemicals that can change consciousness by acting on 5-HT2A receptors [].
There is limited knowledge concerning the online interest in psychedelics that we can extrapolate via trends websites. Objective: We aim to examine the online information-seeking behavior concerning the most popular psychedelics, including cannabis—a quasi-psychedelic—in the European Union EU members of interest and the UK before and during the pandemic.
Methods: We designed a "dictionary" of terms to extract online search data from Google Trends concerning psychedelics and cannabis from Jan to 1-Jan We conducted a triple Holt-Winters exponential smoothing—additive model—for time series analysis to infer seasonality [4, 5]. We utilized hierarchical clustering—an unsupervised machine learning method—to explore clusters of countries concerning the spatial geographic mapping of these chemicals.
We also implemented—a t-test—for comparing the slope difference of two trends before versus during the pandemic. Results: There was an evident seasonal pattern for cannabis, NBOMe, and psilocybin in almost all nations of interest. Similar patterns existed in France and the UK, while those in Germany, Sweden, and Romania had relatively shorter periodicity. Analysis of slopes and hierarchical clustering conveyed differentiated patterns concerning the temporal and spatial mapping, respectively, while contrasting the two periods before versus during the pandemic.
Conclusion: Cannabis and psychedelics follow somewhat a consistent pattern concerning seasonality across Europe; some correlate with the seasonal harvesting of mushrooms, and others with public holidays, including Christmas, the new year holiday, or school breaks. The pandemic influenced some significant changes concerning the online interest in the EU and the UK; nonetheless, we should rely on more rigorous longitudinal and experimental study designs—possessing a superior level of evidence—to confirm the causal relationship.
However, these patterns might be insightful for decision-makers and regulatory authorities—like the EMCDDA—to prognosticate and prevent addiction catastrophes. Understanding and using time series analyses in addiction research. Carhart-Harris RL. How do psychedelics work?. Current Opinion in Psychiatry. Novel psychoactive substances: types, mechanisms of action, and effects. British Medical Journal.
Robust forecasting with exponential and Holt—Winters smoothing. Journal of Forecasting. Gardner Jr ES. Exponential smoothing: The state of the art—Part II. International Journal of Forecasting. Introduction: Continuous monitoring of the safety profile of drugs is one of the critical processes of pharmacovigilance.
As medical literature might be valuable source of safety data, especially for rare, unlisted, serious cases, all MAHs are obliged to medical literature monitoring MLM in all marketing countries [1].
This approach can be changed through modern automation techniques. Objective: To develop and test a tool for automated monitoring of local literature and enhance drug safety data identification. Methods: Modern programming approaches were used to create PV platform, intended for automated literature screening.
GAMP 5 recommendations were used to prove the validation status. Results: We developed a tool—DrugCard PV platform which screens local medical sources for updates on a weekly basis.
Till May we added around local journals originated from 10 countries that cover different therapeutic areas. Our tool automatically searches for defined keywords drug trade names, active substances in published articles. Different file formats can be screened including text, pdfs, images etc. In case a new issue of a journal is published—a PV specialist will receive an email notification. The mandatory features of a validated computerized system, like audit trail, logs, reports are also present here.
Instead of manual reading of the whole journal issue the user only should read a separate article, analyze whether there is a valuable safety data and label it depending on the content. PV specialists may work together inside the platform and provide a quality check for labeled articles.
Our pilot study of how a new tool may improve the efficiency revealed interesting results.
Comments
Post a Comment